作者:HarmanH等翻译:刘蕊
发布者:翟佳羽审校者:李常虹
目的:
旨在测定脊柱关节炎(SpA)与类风湿关节炎(RA)患者的血清转化生长因子β1(TGF-β1)和胎球蛋白A水平,并确定这些生物标志物与疾病活动度,运动情况和影像学进展之间的关系。
方法:
该研究纳入55例脊柱关节炎和38例类风湿关节炎患者,以及28名健康受试者。对于强直性脊柱炎患者,我们采用巴氏强直性脊柱炎疾病活动指数(BASDAI)评估疾病活动度,巴氏强直性脊柱炎功能指数(BASFI)评估患者功能情况,应用巴氏强直性脊柱炎测量指数(BASMI)评估患者活动情况,影像学进展采用巴氏强直性脊柱炎放射学指数(BASRI)评估。应用酶联免疫吸附试验(ELISA)来确定血清胎球蛋白A和血清转化生长因子β1水平。
结果:
中轴型脊柱关节炎患者和类风湿关节炎患者的胎球蛋白A水平显著高于健康组(P0.01)。在外周型脊柱关节炎患者组和健康受试者组中血清转化生长因子β1和胎球蛋白A水平相似。胎球蛋白A和血清转化生长因子β1水平在中轴型脊柱关节炎、外周型脊柱关节炎和类风湿关节炎患者中呈显著正相关。在中轴型脊柱关节炎患者中,胎球蛋白A水平与巴氏强直性脊柱炎测量指数(BASMI)和巴氏强直性脊柱炎放射学指数(BASRI)显著相关。
结论:
胎球蛋白A可能在中轴型脊柱关节炎患者疾病进展中的某个步骤被活化。
附原文:
AIM:Weinvestigatedtheserumtransforminggrowthfactorbeta1(TGFβ1)andfetuin-Alevels,anddeterminedtherelationshipsbetweenthesebiomarkersanddiseaseactivity,mobilityandradiologicprogressioninpatientswithspondyloarthropathy(SpA)andrheumatoidarthritis(RA).METHOD:Thestudyincluded55patientswithSpAand38patientswithRA,togetherwith28healthysubjects.InASpatients,weassesseddiseaseactivityusingtheBathAnkylosingSpondylitisDiseaseActivityIndex(BASDAI),functionalabilityusingtheBathAnkylosingSpondylitisFunctionalIndex(BASFI),andmobilityusingtheBathAnkylosingSpondylitisMetrologyIndex(BASMI),radiologicprogressionusingtheBathAnkylosingSpondylitisRadiologyIndex(BASRI).Serumfetuin-AandTGFβ1weredeterminedusingenzyme-linkedimmunosorbentassay(ELISA)equipment.RESULTS:Fetuin-AwassignificantlyhigherintheaxialSpAandRAgroupsthaninhealthysubjects(P0.01).SerumTGFβ1andfetuin-AlevelsweresimilarintheperipheralSpAgroupandinhealthysubjects.Asignificantpositivecorrelationwasfoundbetweenthefetuin-AandTGFβ1levelsintheaxialSpA,peripheralSpA,andRAgroups(r=0.,P=0.;r=0.,P=0.04;r=0.,P=0.05,respectively).Significantcorrelationswerefoundbetweenfetuin-AandtheBASMIandBASRIvaluesintheaxialSpApatients(r=0.,P=0.;r=0.,P0.,respectively).CONCLUSION:WeconcludethatFetuin-AmaybeoneofthestepsthatcanbeactiveindiseaseprogressioninaxialSpApatients.
引自:
HarmanH,Tekeo?lu?,GürolG,etal.Comparisonoffetuin-Aandtransforminggrowthfactorbeta1levelsinpatientswithspondyloarthropathiesandrheumatoidarthritis.IntJRheumDis.Jan22.doi:10./-X..[Epubaheadofprint]
北京中科白癜风医院刘云涛如何治疗皮肤白癜风
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